Mucin 2 (MUC2) promoter characterization: an overview
نویسندگان
چکیده
منابع مشابه
Alterations of MUC2 Mucin in Colorectal Adenocarcinoma
359 Abstract: MUC2 is a well-identified intestinal mucin, present predominantly in the small intestine and colon. It is known that pathological alterations in the expression and composition of this mucin occur in several serious diseases related to epithelial surfaces, e.g., carcinoma and colitis ulcerosa. In this study, our aim was to find out whether there are any specific alterations in the ...
متن کاملVasoactive intestinal peptide upregulates MUC2 intestinal mucin via CREB/ATF1.
VIP exerts a spectrum of effects as a potent anti-inflammatory factor. In addition, VIP increases expression of MUC2, a major intestinal secretory mucin. We therefore investigated the effects of VIP on the promoter activity of the 5'-flanking region of the MUC2 gene. VIP activated MUC2 transcription in human colonic epithelial cells via cAMP signaling to ERK and p38. cAMP/Epac/Rap1/B-Raf signal...
متن کاملHuman MUC5AC mucin dimerizes in the rough endoplasmic reticulum, similarly to the MUC2 mucin.
Biosynthetic studies on the human MUC5AC mucin were performed by immunoprecipitations with antisera recognizing only the non-O-glycosylated apomucin in the colon adenocarcinoma cell line LS 174T. Pulse-chase studies and subcellular fractionations showed that MUC5AC formed dimers in the rough endoplasmic reticulum within 15 min of the initiation of biosynthesis. No non-O-glycosylated species lar...
متن کاملExpression of MUC2 epithelial mucin in breast carcinoma.
AIMS To examine the expression of the MUC2 epithelial mucin in breast carcinoma; to relate this to patient survival. METHODS Sections from 210 breast carcinomas were stained with the anti-MUC2 core protein monoclonal antibody, 4F1, using an immunoperoxidase technique. The proportion of tumour cells positively stained and the localisation and intensity of any staining were recorded. Expression...
متن کاملMUC2 is the prominent colonic mucin expressed in ulcerative colitis.
BACKGROUND It has been shown that MUC2 is the prominent mucin synthesised in healthy colon. AIM To identify the predominant mucins in ulcerative colitis (UC) and to study their biosynthesis. METHODS AND RESULTS Mucin was purified from UC resection specimens. This mucin on sodium dodecylsulphate polyacrylamide gel electrophoresis (SDS-PAGE) presented as one, high molecular weight, periodic a...
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ژورنال
عنوان ژورنال: Cell and Tissue Research
سال: 2018
ISSN: 0302-766X,1432-0878
DOI: 10.1007/s00441-018-2916-9